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KMID : 1123920090230030631
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Korean Journal of Oriental Physiology and Pathology
2009 Volume.23 No. 3 p.631 ~ p.638
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Preventive Effects of GLEDITSIAE SPINA Ethanol Extracts and its Fraction on Oxidative Stress and Human LDL Oxidation
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Kim Hyuck
Lee Min-Ja
Lee Hye-Sook
Jung Hyun-Jung
Choi Sung-Kyu
Lee Chang-Sub
Park Won-Hwan
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Abstract
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GLEDITSIAE SPINA (GS) has been used as folk remedies traditionally for treatment of antiphlogistic and antifebrile agents. An ethanol extract and its fraction of GS were assessed to determine the mechanism of its antioxidant activity. Also, inhibitory effect of extract from GS and its fraction measuring the inhibitory effect on -induced human low-density lipoprotein (LDL) oxidation. GS ethanol extract and its fraction exhibited a concentration-dependent reactive oxygen species (ROS) and reactive nitrogen species (RNS) scavenging activities, including trolox equivalent antioxidant capacity (TEAC), OPPH radical, superoxide anion, hydroxyl radicals, peroxynitrite and nitric oxide, using different assay systems. Furthermore, the GS ethanol extract and its fraction showed dose-dependent protection of LDL oxidation induced by . In addition, the GS ethanol extract and its fraction were characterized as containing a high amount of total phenolics. These results suggest that GS ethanol extract and its fraction might be helpful for preventing oxidative stress and protecting LDL oxidation.
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KEYWORD
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GLEDITSIAE SPINA (GS), antioxidant, low-density lipoprotein (LDL), reactive oxygen species (ROS), reactive nitrogen species (RNS)
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